Multivalent ligand-receptor binding interactions in the fibroblast growth factor system produce a cooperative growth factor and heparin mechanism for receptor dimerization.

Pantoliano, M W; Horlick, R A; Springer, B A; Van Dyk, D E; Tobery, T; Wetmore, D R; Lear, J D; Nahapetian, A T; Bradley, J D; Sisk, W P

Pantoliano, M W; Horlick, R A; Springer, B A; Van Dyk, D E; Tobery, T; Wetmore, D R; Lear, J D; Nahapetian, A T; Bradley, J D; Sisk, W P.

Affiliation

Pantoliano MW; Crystallography and Biophysical Chemistry Group, Du Pont Merck Pharmaceutical Company, Wilmington, Delaware 19880.

Biochemistry ; 33(34): 10229-48, 1994 Aug 30.

Article in En | MEDLINE | ID: mdl-7520751

Subject(s)

Fibroblast Growth Factors/metabolism; Heparin/metabolism; Receptors, Fibroblast Growth Factor/metabolism; Amino Acid Sequence; Base Sequence; Binding Sites; Chromatography, Affinity; Cloning, Molecular; DNA, Complementary/genetics; Fibroblast Growth Factor 2/metabolism; Glycosylation; Humans; Ligands; Models, Molecular; Molecular Sequence Data; Pentosan Sulfuric Polyester/metabolism; Protein Binding; Protein Conformation; Receptors, Fibroblast Growth Factor/chemistry; Receptors, Fibroblast Growth Factor/genetics; Thermodynamics

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Collection: 01-internacional Database: MEDLINE Main subject: Heparin / Receptors, Fibroblast Growth Factor / Fibroblast Growth Factors Type of study: Prognostic_studies Limits: Humans Language: En Journal: Biochemistry Year: 1994 Document type: Article Country of publication: United States

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