Procoagulant properties of benign and malignant prostatic tissue.
Br J Urol
; 74(2): 204-9, 1994 Aug.
Article
in En
| MEDLINE
| ID: mdl-7522873
ABSTRACT
OBJECTIVE:
To determine the factor-X activating procoagulant activity (FXAA) of prostatic tissue removed at transurethral resection in a specific chromogenic assay. PATIENTS ANDMETHODS:
FXAA was extracted from transurethrally resected prostatic tissue using a cryofragmentation technique. Tissue from 50 patients with prostate cancer was analysed and compared with that from 36 control patients with benign prostatic-hypertrophy. Enzyme activities were assayed in a two stage chromogenic assay and correlated with conventional markers of tumour aggressiveness.RESULTS:
FXAA was found to be significantly lower (P < 0.001) in tissue from malignant prostates compared with benign prostatic hypertrophy tissue. Loss of FXAA was also related to Gleason grade (P < 0.03), percentage of chips involved by tumour (P < 0.04) and bone scan status (P < 0.02). Using antibody inhibition tests this procoagulant was characterized as being a factor VII/tissue factor complex.CONCLUSIONS:
Malignant change in the prostate is associated with a reduction in FXAA and this may be an important factor in prostatic tumour growth and dissemination.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prostatic Hyperplasia
/
Prostatic Neoplasms
/
Factor Xa
Limits:
Humans
/
Male
Language:
En
Journal:
Br J Urol
Year:
1994
Document type:
Article
Affiliation country:
United kingdom