HER4 expression correlates with cytotoxicity directed by a heregulin-toxin fusion protein.

Siegall, C B; Bacus, S S; Cohen, B D; Plowman, G D; Mixan, B; Chace, D; Chin, D M; Goetze, A; Green, J M; Hellström, I

Siegall, C B; Bacus, S S; Cohen, B D; Plowman, G D; Mixan, B; Chace, D; Chin, D M; Goetze, A; Green, J M; Hellström, I.

Affiliation

Siegall CB; Molecular Immunology Department, Bristol-Myers Squibb, Pharmaceutical Research Institute, Seattle, Washington 98121, USA.

J Biol Chem ; 270(13): 7625-30, 1995 Mar 31.

Article in En | MEDLINE | ID: mdl-7535774

Subject(s)

ADP Ribose Transferases; Cell Survival/drug effects; ErbB Receptors/biosynthesis; Exotoxins/pharmacology; Gene Expression/drug effects; Glycoproteins/pharmacology; Immunotoxins/pharmacology; Virulence Factors; Amino Acid Sequence; Animals; Bacterial Toxins/pharmacology; Base Sequence; Breast Neoplasms; Cell Line; DNA Primers; Exotoxins/biosynthesis; Exotoxins/isolation & purification; Female; Glycoproteins/biosynthesis; Glycoproteins/isolation & purification; Humans; Immunotoxins/isolation & purification; Kidney/metabolism; Kinetics; Leukemia, T-Cell; Lung Neoplasms; Male; Molecular Sequence Data; Neuregulins; Ovarian Neoplasms; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Prostatic Neoplasms; Pseudomonas aeruginosa; RNA, Messenger/metabolism; Rats; Receptor, ErbB-4; Recombinant Fusion Proteins; Tumor Cells, Cultured; Tyrosine/analogs & derivatives; Tyrosine/metabolism; Pseudomonas aeruginosa Exotoxin A

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Collection: 01-internacional Database: MEDLINE Main subject: Glycoproteins / Gene Expression / Cell Survival / Immunotoxins / ADP Ribose Transferases / Virulence Factors / Exotoxins / ErbB Receptors Language: En Journal: J Biol Chem Year: 1995 Document type: Article Affiliation country: United States Country of publication: United States

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