5 alpha-Androstan-3 alpha,17 beta-diol is a hormone: stimulation of cAMP accumulation in human and dog prostate.
J Clin Endocrinol Metab
; 80(7): 2259-62, 1995 Jul.
Article
in En
| MEDLINE
| ID: mdl-7541803
ABSTRACT
5 alpha-Androstan-3 alpha, 17 beta-diol (3 alpha-diol) is a well known metabolite of dihydrostestosterone (DHT) and the concentration of its glucuronide in serum is looked upon as a marker of DHT activity in skin and prostate. The data in this communication show that 3 alpha-diol is a potent agonist of the human and canine prostatic SHBG-[SHBG receptor]. It causes a robust rise in intracellular cAMP within minutes; the 1/2 max. response occurs at a concentration equal to its concentration in male plasma. Estradiol is the only other agonist in this system. All other steroids that bind to SHBG are antagonists.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prostate
/
Cyclic AMP
/
Androstane-3,17-diol
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
J Clin Endocrinol Metab
Year:
1995
Document type:
Article
Affiliation country:
United States