Growth of Staphylococcus aureus with nafcillin in vitro induces alpha-toxin production and increases the lethal activity of sterile broth filtrates in a murine model.

Kernodle, D S; McGraw, P A; Barg, N L; Menzies, B E; Voladri, R K; Harshman, S

Kernodle, D S; McGraw, P A; Barg, N L; Menzies, B E; Voladri, R K; Harshman, S.

Affiliation

Kernodle DS; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

J Infect Dis ; 172(2): 410-9, 1995 Aug.

Article in En | MEDLINE | ID: mdl-7542686

Subject(s)

Nafcillin/pharmacology; Staphylococcal Infections/microbiology; Staphylococcus aureus/metabolism; Type C Phospholipases/biosynthesis; Animals; Coagulase/biosynthesis; Coagulase/genetics; Culture Media; Drug Resistance, Microbial; Gene Expression Regulation, Bacterial; Hemolysin Proteins/biosynthesis; Hemolysin Proteins/genetics; Male; Mice; Neutralization Tests; Phosphoric Monoester Hydrolases/biosynthesis; Phosphoric Monoester Hydrolases/genetics; RNA, Bacterial/analysis; RNA, Messenger/genetics; Staphylococcal Infections/mortality; Staphylococcus aureus/drug effects; Staphylococcus aureus/pathogenicity; Survival Rate; Type C Phospholipases/genetics; beta-Lactamases/biosynthesis; beta-Lactamases/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Type C Phospholipases / Staphylococcal Infections / Staphylococcus aureus / Nafcillin Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Infect Dis Year: 1995 Document type: Article Affiliation country: United States

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