Phorbol ester-induced down modulation of tailless CD4 receptors requires prior binding of gp120 and suggests a role for accessory molecules.

Golding, H; Dimitrov, D S; Manischewitz, J; Broder, C C; Robinson, J; Fabian, S; Littman, D R; Lapham, C K

Golding, H; Dimitrov, D S; Manischewitz, J; Broder, C C; Robinson, J; Fabian, S; Littman, D R; Lapham, C K.

Affiliation

Golding H; Division of Viral Products, CBER, Food and Drug Administration, Bethesda, Maryland 20892, USA.

J Virol ; 69(10): 6140-8, 1995 Oct.

Article in En | MEDLINE | ID: mdl-7545243

Subject(s)

CD4 Antigens/physiology; HIV Envelope Protein gp120/metabolism; HIV-1/physiology; Tetradecanoylphorbol Acetate/pharmacology; Animals; Antibodies, Monoclonal/pharmacology; CD4 Antigens/drug effects; Cell Line; Cell Membrane/physiology; Chlorocebus aethiops; Down-Regulation/drug effects; Epitopes/immunology; Giant Cells; HIV Envelope Protein gp120/pharmacology; HeLa Cells; Humans; Kinetics; Membrane Fusion; Mice; Recombinant Proteins/drug effects; Recombinant Proteins/metabolism; Transfection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tetradecanoylphorbol Acetate / CD4 Antigens / HIV Envelope Protein gp120 / HIV-1 Limits: Animals / Humans Language: En Journal: J Virol Year: 1995 Document type: Article Affiliation country: United States Country of publication: United States

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