Characteristic antitumor activity of cytarabine ocfosfate against human colorectal adenocarcinoma xenografts in nude mice.
Cancer Chemother Pharmacol
; 36(6): 459-62, 1995.
Article
in En
| MEDLINE
| ID: mdl-7554036
ABSTRACT
The antitumor activity of cytarabine ocfosfate (SPAC) was tested against human colorectal, gastric and lung adenocarcinoma xenografts in nude mice in comparison with the activities of various antitumor drugs used clinically. SPAC showed higher therapeutic efficacy against human colorectal adenocarcinoma xenografts than against human gastric and lung adenocarcinoma xenografts. SPAC was effective against three of four human colorectal adenocarcinoma xenografts, with efficacy higher than that of 1-beta-D-arabinofuranosylcytosine, fluorouracil, cisplatin, doxorubicin, pirarubicin and vindesine sulfate, but lower than that of mitomycin C and cyclophosphamide. These results indicate that SPAC may be useful for induction and/or postoperative chemotherapy against colorectal adenocarcinomas.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arabinonucleotides
/
Colorectal Neoplasms
/
Adenocarcinoma
/
Cytidine Monophosphate
/
Antineoplastic Agents
Limits:
Animals
/
Humans
Language:
En
Journal:
Cancer Chemother Pharmacol
Year:
1995
Document type:
Article
Affiliation country:
Japan