Synthesis and anticonvulsant activity of N-benzylpyrrolo[2,3-d]-, -pyrazolo[3,4-d]-, and -triazolo[4,5-d]pyrimidines: imidazole ring-modified analogues of 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine.

Kelley, J L; Davis, R G; McLean, E W; Glen, R C; Soroko, F E; Cooper, B R

Kelley, J L; Davis, R G; McLean, E W; Glen, R C; Soroko, F E; Cooper, B R.

Affiliation

Kelley JL; Division of Organic Chemistry, Burroughs Wellcome Co., Research Triangle Park, North Carolina 27709, USA.

J Med Chem ; 38(19): 3884-8, 1995 Sep 15.

Article in En | MEDLINE | ID: mdl-7562920

Subject(s)

Anticonvulsants/chemical synthesis; Anticonvulsants/pharmacology; Purines/chemical synthesis; Purines/pharmacology; Pyrimidines/chemical synthesis; Pyrimidines/pharmacology; Animals; Anticonvulsants/chemistry; Male; Purines/chemistry; Pyrimidines/chemistry; Rats; Rats, Wistar; Seizures/drug therapy; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Purines / Pyrimidines / Anticonvulsants Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1995 Document type: Article Affiliation country: United States

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