Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor.
Nature
; 377(6548): 397-404, 1995 Oct 05.
Article
in En
| MEDLINE
| ID: mdl-7566114
ABSTRACT
Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressors of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Repressor Proteins
/
Receptors, Thyroid Hormone
/
Nuclear Proteins
/
Gene Expression Regulation
/
Receptors, Retinoic Acid
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Nature
Year:
1995
Document type:
Article
Affiliation country:
United States