Involvement of folic acid in the synthesis of membrane-associated nucleotide sugars by normal and transformed mouse fibroblasts.
Cancer Lett
; 96(2): 233-7, 1995 Sep 25.
Article
in En
| MEDLINE
| ID: mdl-7585462
ABSTRACT
A plasma-membrane-containing fraction isolated from Swiss mouse (3T3) fibroblasts was found to contain uridine diphosphate sugars and methyl-uridine diphosphate (mUDP) sugars. The synthesis of the mUDP sugars by membrane preparations of normal and transformed 3T3 cells occurred from the intrinsic membrane uridine-diphosphate sugars + methylenetetrahydrofolic acid. Compared to the normal 3T3 cells, the synthesis of mUDP sugars by the transformed 3T3 cells was reduced by 49%. It is proposed that the plasma-membrane-associated mUDP sugars may be essential for normal cell growth.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Uridine Diphosphate Sugars
/
Cell Membrane
/
Folic Acid
/
Nucleoside Diphosphate Sugars
Type of study:
Risk_factors_studies
Limits:
Animals
Language:
En
Journal:
Cancer Lett
Year:
1995
Document type:
Article
Affiliation country:
United States