Mucin allows survival of Salmonella typhi within mouse peritoneal macrophages.
Biol Res
; 26(3): 371-9, 1993.
Article
in En
| MEDLINE
| ID: mdl-7606257
ABSTRACT
Salmonella typhi is a facultative intracellular human specific pathogen. Both immunocompetent and immunodeficient mice are resistant to S. typhi. However, when they are infected with S. typhi suspended in mucin, the bacteria become pathogenic and infect peritoneal phagocytic cells. The LD50 for mice was 10(5) bacteria suspended in 5% mucin; mouse survival was approximately 48 hours after injection. A high number of bacteria was recovered from peritoneal cells; transmission electron microscopy disclosed a large number of vesicles filled with S. typhi cells in peritoneal cells from infected animals. The addition of mucin to cultures of the reticuloendothelial cell line J774.3 also allowed invasion of the mammalian cells with S. typhi. These data indicate that mucin allows intracellular survival of S. typhi.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Salmonella typhi
/
Macrophages, Peritoneal
/
Mucins
Limits:
Animals
Language:
En
Journal:
Biol Res
Journal subject:
BIOLOGIA
Year:
1993
Document type:
Article