Ethanol enhancement of the motor-stimulating effect of nicotine in the rat.
Alcohol
; 12(3): 217-20, 1995.
Article
in En
| MEDLINE
| ID: mdl-7639954
ABSTRACT
Although ethanol stimulates locomotion in mice, it has been difficult to demonstrate such an action in rats. In contrast, nicotine has been shown to enhance locomotion, including ipsiversive rotation in nigral-lesioned rats. We found no significant effect of ethanol alone on rat rotation at doses of 0.125, 0.50, 1.0, and 2.0 g/kg, IP, during a 30-min observation period. However, there was a dose-dependent effect of ethanol enhancing the rotation induced by nicotine (0.4 mg/kg, SC) given 30 min after the ethanol. The interaction of ethanol and nicotine on locomotion most likely involves the release of dopamine and may be related to the motor abnormalities sometimes seen clinically.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ethanol
/
Motor Activity
/
Nicotine
Limits:
Animals
Language:
En
Journal:
Alcohol
Journal subject:
TRANSTORNOS RELACIONADOS COM SUBSTANCIAS
Year:
1995
Document type:
Article
Affiliation country:
United States
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA