Molecular analysis of 13 cases of MLL/11q23 secondary acute leukemia and identification of topoisomerase II consensus-binding sequences near the chromosomal breakpoint of a secondary leukemia with the t(4;11).

Domer, P H; Head, D R; Renganathan, N; Raimondi, S C; Yang, E; Atlas, M

Domer, P H; Head, D R; Renganathan, N; Raimondi, S C; Yang, E; Atlas, M.

Affiliation

Domer PH; Department of Pathology, Northwestern University Medical School, Chicago, IL 60611, USA.

Leukemia ; 9(8): 1305-12, 1995 Aug.

Article in En | MEDLINE | ID: mdl-7643617

Subject(s)

Chromosome Aberrations/genetics; Chromosomes, Human, Pair 11; DNA Topoisomerases, Type II/metabolism; DNA-Binding Proteins/genetics; Leukemia/pathology; Proto-Oncogenes; Transcription Factors; Acute Disease; Adolescent; Adult; Base Sequence; Binding Sites; Child; Child, Preschool; Chromosome Disorders; Chromosomes, Human, Pair 4; Cloning, Molecular; Consensus Sequence; DNA Primers/chemistry; Female; Histone-Lysine N-Methyltransferase; Humans; Leukemia/genetics; Male; Molecular Sequence Data; Myeloid-Lymphoid Leukemia Protein; Polymorphism, Restriction Fragment Length; Restriction Mapping; Translocation, Genetic

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Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Chromosomes, Human, Pair 11 / Proto-Oncogenes / Leukemia / Chromosome Aberrations / DNA Topoisomerases, Type II / DNA-Binding Proteins Type of study: Diagnostic_studies / Prognostic_studies Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 1995 Document type: Article Affiliation country: United States Country of publication: United kingdom

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