Structure of and kinetic channelling in bifunctional dihydrofolate reductase-thymidylate synthase.

Knighton, D R; Kan, C C; Howland, E; Janson, C A; Hostomska, Z; Welsh, K M; Matthews, D A

Knighton, D R; Kan, C C; Howland, E; Janson, C A; Hostomska, Z; Welsh, K M; Matthews, D A.

Affiliation

Knighton DR; Agouron Pharmaceuticals, Inc., San Diego, California 92121-1122, USA.

Nat Struct Biol ; 1(3): 186-94, 1994 Mar.

Article in En | MEDLINE | ID: mdl-7656037

Subject(s)

Multienzyme Complexes/chemistry; Tetrahydrofolate Dehydrogenase/chemistry; Thymidylate Synthase/chemistry; Amino Acid Sequence; Animals; Binding Sites; Electrochemistry; Escherichia coli/enzymology; Escherichia coli/genetics; Humans; Kinetics; Leishmania major/enzymology; Leishmania major/genetics; Models, Molecular; Molecular Sequence Data; Molecular Structure; Multienzyme Complexes/genetics; Multienzyme Complexes/metabolism; Protein Conformation; Sequence Homology, Amino Acid; Tetrahydrofolate Dehydrogenase/genetics; Tetrahydrofolate Dehydrogenase/metabolism; Thymidylate Synthase/genetics; Thymidylate Synthase/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Tetrahydrofolate Dehydrogenase / Thymidylate Synthase / Multienzyme Complexes Limits: Animals / Humans Language: En Journal: Nat Struct Biol Journal subject: BIOLOGIA MOLECULAR Year: 1994 Document type: Article Affiliation country: United States Country of publication: United States

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