Enhanced expression of common fragile site with occupational exposure to pesticides.
Cancer Genet Cytogenet
; 82(2): 123-7, 1995 Jul 15.
Article
in En
| MEDLINE
| ID: mdl-7664241
ABSTRACT
The expression of common fragile sites (FS), induced by aphidicolin, in subjects with occupational history of exposure to pesticides has been studied. Results showed a higher frequency of FS in exposed subjects; in particular, there was an elevated expression of FS at the cancer breakpoints 3p14, 5q31, 7q22, 7q32, 14q24, and 16q22, involved in leukemias and non-Hodgkin's lymphoma. Moreover, the frequency of breaks in chromosomal bands carrying oncogenes or tumor suppressor genes involved in aberrations was significantly higher in exposed subjects at sites 1q25, 3p25, 7p22, 8q24.1, and 13q14.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Occupational Exposure
/
Chromosome Fragility
/
Aphidicolin
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Cancer Genet Cytogenet
Year:
1995
Document type:
Article
Affiliation country:
Italy