Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase.

Anlezark, G M; Melton, R G; Sherwood, R F; Wilson, W R; Denny, W A; Palmer, B D; Knox, R J; Friedlos, F; Williams, A

Anlezark, G M; Melton, R G; Sherwood, R F; Wilson, W R; Denny, W A; Palmer, B D; Knox, R J; Friedlos, F; Williams, A.

Affiliation

Anlezark GM; Centre for Applied Microbiology and Research, Porton Down, Salisbury, Wilts, U.K.

Biochem Pharmacol ; 50(5): 609-18, 1995 Aug 25.

Article in En | MEDLINE | ID: mdl-7669063

Subject(s)

Aniline Mustard/analogs & derivatives; Antineoplastic Agents/metabolism; Aziridines/metabolism; Escherichia coli/enzymology; Nitroreductases/metabolism; Prodrugs/metabolism; Aniline Mustard/metabolism; Aniline Mustard/pharmacology; Animals; Antineoplastic Agents/pharmacology; Aziridines/pharmacology; Biotransformation; Cell Line; Cricetinae; Kinetics; Oxidation-Reduction; Prodrugs/pharmacology; Substrate Specificity

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Aziridines / Nitroreductases / Prodrugs / Escherichia coli / Aniline Mustard / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: Biochem Pharmacol Year: 1995 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

Search on Google

Add to My VHL

XML

PubMed Links