Suppression of calphobindin I (CPB I) production in carcinoma of uterine cervix and endometrium.
Gynecol Oncol
; 58(3): 295-300, 1995 Sep.
Article
in En
| MEDLINE
| ID: mdl-7672695
ABSTRACT
Calphobindin I (CPB I) is a member of the family of Ca(2+)-dependent phospholipid binding proteins collectively termed as annexins. CPB I (Annexin V) has recently been shown to be an endogenous inhibitor of protein kinase C, a key enzyme in the cellular signal transduction and its inhibition by CPB I is presumed to be related ultimately to carcinogenesis. We therefore examined the level of production of CPB I in uterine cancer cells. Immunohistochemical analysis, northern blot, and in situ hybridization showed that the production of CPB I was markedly suppressed at the level of transcription in both cervical and endometrial carcinoma cells when compared to their normal counterparts. Decrease in production of CPB I may lead to dysregulated activation of protein kinase C and, accordingly, may be involved in a disorder of cell differentiation, proliferation, and carcinogenesis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma
/
Uterine Cervical Neoplasms
/
Annexin A5
/
Endometrium
Limits:
Female
/
Humans
Language:
En
Journal:
Gynecol Oncol
Year:
1995
Document type:
Article
Affiliation country:
Japan