Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively.

Valius, M; Bazenet, C; Kazlauskas, A

Valius, M; Bazenet, C; Kazlauskas, A.

Affiliation

Valius M; National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206.

Mol Cell Biol ; 13(1): 133-43, 1993 Jan.

Article in En | MEDLINE | ID: mdl-7678051

Subject(s)

Receptors, Platelet-Derived Growth Factor/metabolism; Type C Phospholipases/metabolism; Tyrosine/analogs & derivatives; Animals; Base Sequence; Cells, Cultured; Consensus Sequence; Cytoplasm/metabolism; Dogs; Humans; In Vitro Techniques; Inositol Phosphates/metabolism; Macromolecular Substances; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides/chemistry; Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein Binding; Receptors, Platelet-Derived Growth Factor/chemistry; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/metabolism; Signal Transduction; Structure-Activity Relationship; Tyrosine/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Type C Phospholipases / Tyrosine / Receptors, Platelet-Derived Growth Factor Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Cell Biol Year: 1993 Document type: Article

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