Rat submandibular and parotid protein phosphorylation and exocytosis: effect of site-selective cAMP analogs.
Crit Rev Oral Biol Med
; 4(3-4): 443-8, 1993.
Article
in En
| MEDLINE
| ID: mdl-7690603
ABSTRACT
A series of cAMP analogs that have different specificities for the two different binding sites on the regulatory subunit of type I and type II cAMP-dependent protein kinase (PKA) were used to determine whether selective activation of type I or type II PKA could link either or both isozyme forms of PKA with exocytosis and specific protein phosphorylation in salivary gland cells. Using dispersed rat submandibular or parotid cells, selective activation of either type I or type II resulted in a synergistic response for both rat submandibular mucin and parotid amylase secretion and the phosphorylation of a 26-kDa integral membrane phosphoprotein. These data suggest that the activation of either isozyme of PKA can elicit cellular exocytosis and specific protein phosphorylation in both of these cell types.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parotid Gland
/
Protein Kinases
/
Salivary Proteins and Peptides
/
Submandibular Gland
/
Cyclic AMP
/
Isoenzymes
Limits:
Animals
Language:
En
Journal:
Crit Rev Oral Biol Med
Journal subject:
ODONTOLOGIA
Year:
1993
Document type:
Article