Reductive chemistry of the novel hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.

Palmer, B D; van Zijl, P; Denny, W A; Wilson, W R

Palmer, B D; van Zijl, P; Denny, W A; Wilson, W R.

Affiliation

Palmer BD; Cancer Research Laboratory, University of Auckland School of Medicine, New Zealand.

J Med Chem ; 38(7): 1229-41, 1995 Mar 31.

Article in En | MEDLINE | ID: mdl-7707325

Subject(s)

Aniline Mustard/analogs & derivatives; Antineoplastic Agents; Cell Division/drug effects; Hypoxia; Nitrogen Mustard Compounds/toxicity; Aniline Mustard/pharmacology; Cell Line; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; In Vitro Techniques; Nitrogen Mustard Compounds/chemical synthesis; Nitrogen Mustard Compounds/chemistry; Oxidation-Reduction; Prodrugs/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Cell Division / Aniline Mustard / Hypoxia / Antineoplastic Agents / Nitrogen Mustard Compounds Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1995 Document type: Article Affiliation country: New Zealand Country of publication: United States

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