Roles of beta-galactosidase of B lymphocytes and sialidase of T lymphocytes in inflammation-primed activation of macrophages.
Immunol Lett
; 43(3): 143-8, 1994 Dec.
Article
in En
| MEDLINE
| ID: mdl-7721326
ABSTRACT
The outer surface of mouse B lymphocytes carries constitutive and inducible beta-galactosidase isozymes. A brief (30 min) treatment of B lymphocytes with lysophosphatidylcholine (lyso-Pc) immediately induced an approximate 3-fold higher beta-galactosidase activity than the constitutive isozyme of untreated B lymphocytes. Thus, the lyso-Pc-inducible isozyme is not a de novo enzyme. Outer surface of mouse T lymphocytes carries constitutive (non-Neu-1) and inducible (Neu-1) sialidase isozymes. The lyso-Pc-inducible beta-galactosidase of B lymphocytes and the Neu-1 sialidase of T lymphocytes were required for conversion of vitamin D3-binding protein (Gc protein) to a potent macrophage activating factor. This enzymatic generation of the macrophage activating factor was mediated via enzyme-associated receptors.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
B-Lymphocytes
/
T-Lymphocytes
/
Beta-Galactosidase
/
Macrophages, Peritoneal
/
Inflammation
/
Macrophage Activation
/
Neuraminidase
Limits:
Animals
Language:
En
Journal:
Immunol Lett
Year:
1994
Document type:
Article