The effect of levcromakalim (BRL 38227) on bladder function in patients with high spinal cord lesions.
Br J Clin Pharmacol
; 39(2): 207-9, 1995 Feb.
Article
in En
| MEDLINE
| ID: mdl-7742166
ABSTRACT
The effects of the potassium channel opener levcromakalim (BRL 38227) 7.5 micrograms kg-1 were examined on urodynamic variables and blood pressure during inflow and voiding cystometry in six high spinal cord lesion patients. Levcromakalim administration significantly increased the duration of bladder contraction (197 +/- 128 s to 267 +/- 167 s, P < 0.05) and also reduced blood pressure (126 +/- 13/67 +/- 9 mm Hg to 104 +/- 25/52 +/- 12 mm Hg) but was without effect on other urodynamic parameters. Because of concerns about hypotensive responses, further studies involving higher doses of levcromakalim should be considered only if the drug was administered intravesically.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrroles
/
Spinal Cord Injuries
/
Urodynamics
/
Benzopyrans
/
Urinary Bladder, Neurogenic
/
Blood Pressure
/
Potassium Channels
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Br J Clin Pharmacol
Year:
1995
Document type:
Article
Affiliation country:
Australia