[Study of mdm2 gene amplification in primary breast tumors]. / Etude de l'amplification du gène mdm2 dans les tumeurs primitives du sein.
Bull Cancer
; 81(7): 587-92, 1994 Jul.
Article
in Fr
| MEDLINE
| ID: mdl-7742600
ABSTRACT
mdm2 (mouse double minute) protein seems lead to p53 inactivation and therefore might potentially play a role in carcinogenesis. We have studied mdm2 gene amplification from 239 primary breast cancer tissues. mdm2 gene was amplified in 10% of cases (25/239). mdm2 amplification was associated with c-erbB2 amplification (P < 10(-3)). No other correlation was found. However there was inverse correlation between c-erbB2 gene amplification and hormonal receptors (P < 10(-4)), only from patients without mdm2 gene amplification.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Nuclear Proteins
/
Proteins
/
Gene Amplification
/
Proto-Oncogene Proteins
/
Carcinoma, Lobular
/
Carcinoma, Ductal, Breast
/
Neoplasm Proteins
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Language:
Fr
Journal:
Bull Cancer
Year:
1994
Document type:
Article
Affiliation country:
France