Selective effects of retinal dopamine depletion on partial ischemia-induced electroretinographic hyperresponses in rabbits.
Doc Ophthalmol
; 88(1): 89-97, 1994.
Article
in En
| MEDLINE
| ID: mdl-7743916
ABSTRACT
The interaction of retinal dopamine depletion and partial ischemia on the a- and b-wave amplitudes and implicit times of the electroretinogram was examined in adult pigmented rabbits. Seven days after 6-hydroxydopamine treatment, which resulted in a depletion of the amine, partial retinal ischemia was induced by raising the intraocular pressure. As expected, moderate elevation of intraocular pressure produced increases in both a- and b-wave amplitudes. Amplitude hyperresponses were significantly reduced in dopamine-depleted retinas. These reductions were more prominent with relatively lower intensities. However, response delays were not shortened but lengthened by 6-hydroxydopamine pretreatment. Together, these results point to a selective role of dopamine in partial retinal ischemia induced by moderate elevation of intraocular pressure in rabbits.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Retina
/
Retinal Vessels
/
Dopamine
/
Ischemia
Limits:
Animals
Language:
En
Journal:
Doc Ophthalmol
Year:
1994
Document type:
Article
Affiliation country:
Canada