Naive CD28-deficient T cells can initiate but not sustain an in vitro antigen-specific immune response.

Lucas, P J; Negishi, I; Nakayama, K; Fields, L E; Loh, D Y

Lucas, P J; Negishi, I; Nakayama, K; Fields, L E; Loh, D Y.

Affiliation

Lucas PJ; Howard Hughes Medical Institute, Washington School of Medicine, St. Louis, MO 63110, USA.

J Immunol ; 154(11): 5757-68, 1995 Jun 01.

Article in En | MEDLINE | ID: mdl-7751626

Subject(s)

CD28 Antigens/genetics; CD28 Antigens/physiology; Immunoconjugates; Lymphocyte Activation/immunology; T-Lymphocytes/immunology; Abatacept; Amino Acid Sequence; Animals; Antibodies, Monoclonal/immunology; Antigens, CD/biosynthesis; Antigens, Differentiation/immunology; Base Sequence; CTLA-4 Antigen; Cells, Cultured; Flow Cytometry; Interleukin-2/immunology; Interleukin-4/immunology; Mice; Mice, Knockout; Molecular Sequence Data; Signal Transduction/immunology; Up-Regulation/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Lymphocyte Activation / T-Lymphocytes / CD28 Antigens / Immunoconjugates Limits: Animals Language: En Journal: J Immunol Year: 1995 Document type: Article Affiliation country: United States Country of publication: United States

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