Cyclosporins from Tolypocladium terricola.

Jegorov, A; Matha, V; Sedmera, P; Havlícek, V; Stuchlík, J; Seidel, P; Simek, P

Jegorov, A; Matha, V; Sedmera, P; Havlícek, V; Stuchlík, J; Seidel, P; Simek, P.

Affiliation

Jegorov A; Galena Co., Research Unit, Ceske Budejovice, Czech Republic.

Phytochemistry ; 38(2): 403-7, 1995 Jan.

Article in En | MEDLINE | ID: mdl-7772305

ABSTRACT

ABSTRACT

New natural cyclosporins were isolated from the mycelium of surface cultivated fungus Tolypocladium terricola. The chemical structures of [Leu4] CS and [MeLeu1] CS = cyclosporin-J, were deduced from the NMR and mass spectral data. Biological activity of new cyclosporins is reported based on the proliferative mitogen stimulation test.

Subject(s)

Cyclosporins/isolation & purification; Mitosporic Fungi/chemistry; Amino Acid Sequence; Animals; Cell Division/drug effects; Cyclosporins/chemistry; Cyclosporins/pharmacology; Female; Lymphocytes/cytology; Lymphocytes/drug effects; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Molecular Structure; Spectrum Analysis

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Cyclosporins / Mitosporic Fungi Limits: Animals Language: En Journal: Phytochemistry Year: 1995 Document type: Article Affiliation country: Czech Republic

Search on Google

Add to My VHL

XML

PubMed Links