The thyrotropin (TSH) receptor transmembrane domain mutation (Pro556-Leu) in the hypothyroid hyt/hyt mouse results in plasma membrane targeting but defective TSH binding.

Gu, W X; Du, G G; Kopp, P; Rentoumis, A; Albanese, C; Kohn, L D; Madison, L D; Jameson, J L

Gu, W X; Du, G G; Kopp, P; Rentoumis, A; Albanese, C; Kohn, L D; Madison, L D; Jameson, J L.

Affiliation

Gu WX; Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA.

Endocrinology ; 136(7): 3146-53, 1995 Jul.

Article in En | MEDLINE | ID: mdl-7789342

Subject(s)

Hypothyroidism/genetics; Leucine/genetics; Mutagenesis, Site-Directed; Proline/genetics; Receptors, Thyrotropin/genetics; Thyrotropin/metabolism; Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Cell Membrane/metabolism; Conserved Sequence; Fluorescent Antibody Technique; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Receptors, Thyrotropin/chemistry; Receptors, Thyrotropin/metabolism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Thyrotropin / Proline / Thyrotropin / Mutagenesis, Site-Directed / Hypothyroidism / Leucine Limits: Animals Language: En Journal: Endocrinology Year: 1995 Document type: Article Affiliation country: United States Country of publication: United States

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