[Comparative study of the influence of fish oil and gemfibrozil on levels of serum lipoprotein in endogenous hypertriglyceridemia]. / Badanie porównawcze wplywu oleju rybnego i gemfibrozilu na poziom lipoprotein surowicy w hipertriglicerydemii endogennej.

ABSTRACT

Hypolipemic action of fish oil and gemfibrozil was compared. The study was performed in 12 men with endogenous hypertriglyceridemia. Subjects received fish oil 12 grams daily (3.6 g of eicosapentaenoic and docosahexaenoic fatty acids) for 3 weeks, and then, after an interval of at least 6 weeks, gemfibrozil in the dose of 900 mg daily. Results after gemfibrozil were compared with those after fish oil. Fish oil was shown to be less effective than gemfibrozil in decreasing concentrations of serum triglycerides and triglycerides and cholesterol in VLDL. However, the difference did not reach the level of statistical significance. The agents differed significantly in their influence on the LDL fraction. Fish oil slightly increased and gemfibrozil significantly decreased LDL-chol level. LDL-apoB increased after fish oil, but did not change after gemfibrozil. It may be concluded that fish oils, although effective in decreasing concentrations of serum triglycerides and lipid components of the VLDL fraction, are not alternative for gemfibrozil in monotherapy of endogenous hypertriglyceridemia.