Bistramides A, B, C, D, and K: a new class of bioactive cyclic polyethers from Lissoclinum bistratum.
J Nat Prod
; 57(10): 1336-45, 1994 Oct.
Article
in En
| MEDLINE
| ID: mdl-7807120
ABSTRACT
The isolation and characterization is described of four novel cyclic polyethers, bistramides B [2], C [3], D [4], and K [5], which are closely related to the previously reported bistramide A [1] from the New Caledonian urochordata Lissoclinum bistratum. The structures of these metabolites were defined by spectroscopic methods. The four compounds exhibited in vitro cytotoxicity toward six tumor cell lines, including the human non-small cell lung carcinoma (NSCLC-N6) line. Cytofluorimetric analysis with bistramide K showed a complete block of NSCLC-N6 cells in the G1 phase. Bistramide D and particularly bistramide K are less toxic than bistramides A, B, and C and are thereby effective in vivo against NSCLC-N6.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Urochordata
/
Ethers, Cyclic
/
Antineoplastic Agents
Limits:
Animals
/
Humans
Language:
En
Journal:
J Nat Prod
Year:
1994
Document type:
Article
Affiliation country:
France