Effects of neutron-gamma irradiation on striatal D1 and D2 receptor distribution.
Neurosci Lett
; 178(1): 107-10, 1994 Aug 29.
Article
in En
| MEDLINE
| ID: mdl-7816316
ABSTRACT
The early effects of neutron irradiation on the striatal D1 and D2 dopaminergic receptor distribution were investigated by quantitative receptor autoradiography. One hour after exposure at the dose of 8.4 Gy, an increase of D1 (+21%) and D2 (+25%) receptor density was observed in the striatum, located at the most anterior levels, containing the richest plexus of dopaminergic fibers afferent from the substantia nigra. Regional differences in changes of D1 and D2 receptor density were observed. This up-regulation could contribute to the development of early radio-induced neuro-vegetative syndrome.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Dopamine D2
/
Receptors, Dopamine D1
/
Corpus Striatum
Limits:
Animals
Language:
En
Journal:
Neurosci Lett
Year:
1994
Document type:
Article
Affiliation country:
France