The effect of MK-0591, a novel 5-lipoxygenase activating protein inhibitor, on leukotriene biosynthesis and allergen-induced airway responses in asthmatic subjects in vivo.

Diamant, Z; Timmers, M C; van der Veen, H; Friedman, B S; De Smet, M; Depré, M; Hilliard, D; Bel, E H; Sterk, P J

Diamant, Z; Timmers, M C; van der Veen, H; Friedman, B S; De Smet, M; Depré, M; Hilliard, D; Bel, E H; Sterk, P J.

Affiliation

Diamant Z; Department of Pulmonology, University Hospital, Leiden, The Netherlands.

J Allergy Clin Immunol ; 95(1 Pt 1): 42-51, 1995 Jan.

Article in En | MEDLINE | ID: mdl-7822663

Subject(s)

Allergens/adverse effects; Asthma/drug therapy; Bronchial Hyperreactivity/drug therapy; Carrier Proteins/antagonists & inhibitors; Indoles/administration & dosage; Leukotriene Antagonists; Leukotrienes/biosynthesis; Membrane Proteins/antagonists & inhibitors; Quinolines/administration & dosage; 5-Lipoxygenase-Activating Proteins; Administration, Oral; Adult; Asthma/metabolism; Asthma/physiopathology; Bronchial Hyperreactivity/metabolism; Bronchial Hyperreactivity/physiopathology; Bronchial Provocation Tests/methods; Creatinine/urine; Double-Blind Method; Forced Expiratory Volume/drug effects; Histamine; Humans; Indoles/blood; Leukotrienes/analysis; Male; Quinolines/blood; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Asthma / Allergens / Carrier Proteins / Leukotrienes / Bronchial Hyperreactivity / Leukotriene Antagonists / Indoles / Membrane Proteins Type of study: Clinical_trials / Prognostic_studies Limits: Adult / Humans / Male Language: En Journal: J Allergy Clin Immunol Year: 1995 Document type: Article Affiliation country: Netherlands

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