Fluorine-18-labeled progestin 16 alpha, 17 alpha-dioxolanes: development of high-affinity ligands for the progesterone receptor with high in vivo target site selectivity.

Buckman, B O; Bonasera, T A; Kirschbaum, K S; Welch, M J; Katzenellenbogen, J A

Buckman, B O; Bonasera, T A; Kirschbaum, K S; Welch, M J; Katzenellenbogen, J A.

Affiliation

Buckman BO; Department of Chemistry, University of Illinois, Urbana, 61801.

J Med Chem ; 38(2): 328-37, 1995 Jan 20.

Article in En | MEDLINE | ID: mdl-7830275

Subject(s)

Progestins/metabolism; Receptors, Progesterone/metabolism; Animals; Female; Fluorine Radioisotopes; Ovary/metabolism; Progestins/chemical synthesis; Progestins/chemistry; Radioligand Assay; Radionuclide Imaging/methods; Rats; Rats, Sprague-Dawley; Solubility; Structure-Activity Relationship; Tissue Distribution; Uterus/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Progestins / Receptors, Progesterone Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1995 Document type: Article

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