Qualitative study of drug resistance in retroviral protease using structural modeling and site-directed mutagenesis.

Culberson, J C; Bush, B L; Sardana, V V

Culberson, J C; Bush, B L; Sardana, V V.

Affiliation

Culberson JC; Department of Molecular Systems, Merck Research Laboratories, West Point, Pennsylvania 19486.

Methods Enzymol ; 241: 385-94, 1994.

Article in En | MEDLINE | ID: mdl-7854190

Subject(s)

Antiviral Agents/pharmacology; Aspartic Acid Endopeptidases/chemistry; Computer Simulation; Drug Resistance, Microbial; Models, Molecular; Protein Conformation; Retroviridae Proteins/chemistry; Retroviridae/drug effects; Amino Acid Sequence; Antiviral Agents/chemistry; Aspartic Acid Endopeptidases/antagonists & inhibitors; Aspartic Acid Endopeptidases/genetics; Binding Sites; HIV Protease/chemistry; HIV Protease/genetics; HIV Protease Inhibitors/chemistry; HIV Protease Inhibitors/pharmacology; HIV-1/drug effects; HIV-1/enzymology; HIV-2/drug effects; HIV-2/enzymology; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Retroviridae/genetics; Retroviridae Proteins/antagonists & inhibitors; Retroviridae Proteins/genetics; Software; Substrate Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Protein Conformation / Retroviridae / Computer Simulation / Drug Resistance, Microbial / Models, Molecular / Retroviridae Proteins / Aspartic Acid Endopeptidases Type of study: Qualitative_research Language: En Journal: Methods Enzymol Year: 1994 Document type: Article

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