Rapid decline in folylpolyglutamate synthetase activity and gene expression during maturation of HL-60 cells. Nature of the effect, impact on folate compound polyglutamate pools, and evidence for programmed down-regulation during maturation.

Egan, M G; Sirlin, S; Rumberger, B G; Garrow, T A; Shane, B; Sirotnak, F M

Egan, M G; Sirlin, S; Rumberger, B G; Garrow, T A; Shane, B; Sirotnak, F M.

Affiliation

Egan MG; Program in Molecular Pharmacology and Therapeutics, Memorial Sloan-Kettering Cancer Center, New York, New York.

J Biol Chem ; 270(10): 5462-8, 1995 Mar 10.

Article in En | MEDLINE | ID: mdl-7890662

Subject(s)

Dimethyl Sulfoxide/pharmacology; Gene Expression Regulation, Enzymologic; Methotrexate/metabolism; Peptide Synthases/metabolism; Pteroylpolyglutamic Acids/metabolism; Blotting, Northern; Cell Division/drug effects; Cell Line; Gene Expression Regulation, Neoplastic; Humans; Hypoxanthine; Hypoxanthines/pharmacology; Kinetics; Leukemia, Promyelocytic, Acute; Methotrexate/pharmacology; Peptide Synthases/biosynthesis; RNA, Messenger/analysis; RNA, Messenger/biosynthesis; Thymidine/pharmacology; Time Factors; Tumor Cells, Cultured; gamma-Glutamyl Hydrolase/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Peptide Synthases / Gene Expression Regulation, Enzymologic / Pteroylpolyglutamic Acids / Dimethyl Sulfoxide / Methotrexate Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 1995 Document type: Article Country of publication: United States

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