Possible incorporation of an immunotoxicological functional assay for assessing humoral immunity for hazard identification purposes in rats on standard toxicology study.

Ladics, G S; Smith, C; Heaps, K; Elliott, G S; Slone, T W; Loveless, S E

Ladics, G S; Smith, C; Heaps, K; Elliott, G S; Slone, T W; Loveless, S E.

Affiliation

Ladics GS; E.I. du Pont de Nemours and Co., Haskell Laboratory for Toxicology and Industrial Medicine, Newark, DE 19714.

Toxicology ; 96(3): 225-38, 1995 Feb 27.

Article in En | MEDLINE | ID: mdl-7900163

Subject(s)

Antibody Formation/drug effects; Cyclophosphamide/toxicity; Spleen/drug effects; Animals; Antibody Formation/immunology; Cyclophosphamide/administration & dosage; Cyclophosphamide/metabolism; Enzyme-Linked Immunosorbent Assay; Erythrocyte Transfusion; Erythrocytes/immunology; Feasibility Studies; Immunoglobulin M/blood; Injections, Intraperitoneal; Leukocyte Count; Liver/drug effects; Liver/pathology; Lymphoid Tissue/drug effects; Lymphoid Tissue/pathology; Male; Rats; Rats, Sprague-Dawley; Sheep; Spleen/cytology; Spleen/pathology

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Collection: 01-internacional Database: MEDLINE Main subject: Spleen / Cyclophosphamide / Antibody Formation Type of study: Diagnostic_studies / Guideline / Prognostic_studies Limits: Animals Language: En Journal: Toxicology Year: 1995 Document type: Article

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