The sensitivity of IL-4 production for cAMP inducers is lost in CD4+ T cells from aged mice.

Dobber, R; van den Bergh, P; Tielemans, M; Schuitemaker, J; Nagelkerken, L

Dobber, R; van den Bergh, P; Tielemans, M; Schuitemaker, J; Nagelkerken, L.

Affiliation

Dobber R; Section of Immunology, Institute of Aging and Vascular Research TNO, Leiden, The Netherlands.

Int Immunol ; 5(9): 1167-76, 1993 Sep.

Article in En | MEDLINE | ID: mdl-7902131

Subject(s)

Aging/physiology; CD4-Positive T-Lymphocytes/metabolism; Cyclic AMP/biosynthesis; Interleukin-4/biosynthesis; Animals; Antigen-Presenting Cells; CD4-Positive T-Lymphocytes/drug effects; Cells, Cultured; Colforsin/pharmacology; Concanavalin A/pharmacology; Dinoprostone/pharmacology; Enzyme Induction; Immunophenotyping; Interleukin-2/biosynthesis; Lymphocyte Activation/drug effects; Male; Mice; Mice, Inbred CBA

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Collection: 01-internacional Database: MEDLINE Main subject: Aging / CD4-Positive T-Lymphocytes / Interleukin-4 / Cyclic AMP Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Int Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 1993 Document type: Article Affiliation country: Netherlands Country of publication: United kingdom

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