Synthesis and structure-activity relationships of new antitumor taxoids. Effects of cyclohexyl substitution at the C-3' and/or C-2 of taxotere (docetaxel).

Ojima, I; Duclos, O; Zucco, M; Bissery, M C; Combeau, C; Vrignaud, P; Riou, J F; Lavelle, F

Ojima, I; Duclos, O; Zucco, M; Bissery, M C; Combeau, C; Vrignaud, P; Riou, J F; Lavelle, F.

Affiliation

Ojima I; Department of Chemistry, State University of New York at Stony Brook 11794-3400.

J Med Chem ; 37(16): 2602-8, 1994 Aug 05.

Article in En | MEDLINE | ID: mdl-7914541

Subject(s)

Antineoplastic Agents, Phytogenic/chemical synthesis; Paclitaxel/analogs & derivatives; Taxoids; Animals; Antineoplastic Agents, Phytogenic/pharmacology; Antineoplastic Agents, Phytogenic/therapeutic use; Docetaxel; Doxorubicin; Drug Resistance; Leukemia P388/drug therapy; Melanoma, Experimental/drug therapy; Mice; Microtubules/drug effects; Molecular Structure; Paclitaxel/chemistry; Paclitaxel/pharmacology; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Paclitaxel / Taxoids / Antineoplastic Agents, Phytogenic Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1994 Document type: Article Country of publication: United States

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