Comparison of the acute biological action of injectable salmon calcitonin and an injectable and oral calcitonin analogue.
Calcif Tissue Int
; 55(1): 71-3, 1994 Jul.
Article
in En
| MEDLINE
| ID: mdl-7922793
ABSTRACT
In most countries, calcitonin is available in the form of injections, and less frequently as an intranasal spray. An oral route of administration should improve compliance. In a preliminary feasibility study, we have compared the acute biological action of injectable salmon calcitonin (50 IU), with the injectable calcitonin analogue ASC 710 (0.2 mg) and oral ASC 710 (20 mg) in 6 patients suffering from active Paget's disease of bone. The intensity and duration of the biological response were not significantly different in the 3 modes of therapy. In conclusion, the oral calcitonin analogue ASC 710 possesses an antiresorbing activity in Paget's disease comparable to that of an injection of salmon calcitonin which demonstrates that it can cross the intestinal barrier.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteitis Deformans
/
Calcitonin
Type of study:
Clinical_trials
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Calcif Tissue Int
Year:
1994
Document type:
Article
Affiliation country:
Belgium