131I-MIBG scintigraphy in neural crest tumours.
Indian J Cancer
; 31(2): 103-10, 1994 Jun.
Article
in En
| MEDLINE
| ID: mdl-7927441
ABSTRACT
Radioiodinated meta-iodobenzylguanidine (131I-MIBG) has been widely used for the diagnosis of neuroblastomas, pheochromocytomas, paragangliomas and medullary carcinomas of thyroid. We have developed a procedure for preparation of 131I-MIBG and studied its utility in diagnosis of primary and metastatic neural crest tumours. Studies were carried out in 54 patients. Of them 39 cases were of neuroblastomas, 1 pheochromocytoma; 6 operated medullary carcinomas; 5 paragangliomas; 2 Ewing's sarcoma and 1 Rhabdomyosarcoma; The sensitivity for the detection of primary tumours of neuroblastomas was 94% and for the detection of metastasis was 83%; while in the case of paragangliomas and medullary carcinoma, the sensitivity was 75% and 70% respectively. Our experience in the present study shows that 131I-MIBG scintigraphy is a sensitive and specific diagnostic tool to localise primary and metastatic disease of neural crest tumours.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bone Neoplasms
/
Thyroid Neoplasms
/
Adrenal Gland Neoplasms
/
Iodine Radioisotopes
/
Iodobenzenes
/
Neuroblastoma
Type of study:
Diagnostic_studies
Limits:
Child
/
Humans
Language:
En
Journal:
Indian J Cancer
Year:
1994
Document type:
Article