The cell type-specific IGF2 expression during early human development correlates to the pattern of overgrowth and neoplasia in the Beckwith-Wiedemann syndrome.
Am J Pathol
; 145(4): 802-17, 1994 Oct.
Article
in En
| MEDLINE
| ID: mdl-7943172
ABSTRACT
Overstimulation by insulin-like growth factor II is implied in several overgrowth conditions and childhood cancers. We have therefore studied spatial and temporal expression patterns of the insulin-like growth factor II gene (IGF2) and the insulin-like growth factor type 1 receptor gene during normal human development (5.5 to 23.0 weeks postfertilization). The set of cell types with the most abundant IGF2 expression correlated strikingly to the organomegaly and tumor predisposition of the Beckwith-Wiedemann syndrome. Intrauterine growth and postnatal organ weights of a prematurely born child with a full-blown syndrome are presented. The cell type-specific IGF2 expression of these organs and of multifocal Wilms' tumors from two other children affected by the Beckwith-Wiedemann syndrome were also studied. The results clarify and extend previous findings concerning human prenatal IGF2 expression and are consistent with a short range overstimulatory role of locally produced IGF II ensuing after the first trimester in the Beckwith-Wiedemann syndrome.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Beckwith-Wiedemann Syndrome
/
Insulin-Like Growth Factor II
/
Gene Expression
/
Embryonic and Fetal Development
/
Fetus
Limits:
Humans
Language:
En
Journal:
Am J Pathol
Year:
1994
Document type:
Article
Affiliation country:
Sweden