Synthesis and structure-activity relationships of a series of penicillin-derived HIV proteinase inhibitors: heterocyclic ring systems containing P1' and P2' substituents.

Kitchin, J; Bethell, R C; Cammack, N; Dolan, S; Evans, D N; Holman, S; Holmes, D S; McMeekin, P; Mo, C L; Nieland, N

Kitchin, J; Bethell, R C; Cammack, N; Dolan, S; Evans, D N; Holman, S; Holmes, D S; McMeekin, P; Mo, C L; Nieland, N.

Affiliation

Kitchin J; Department of Medicinal Chemistry, Glaxo Research and Development Limited, Greenford, Middlesex, United Kingdom.

J Med Chem ; 37(22): 3707-16, 1994 Oct 28.

Article in En | MEDLINE | ID: mdl-7966131

Subject(s)

HIV Protease Inhibitors/chemical synthesis; HIV Protease Inhibitors/pharmacology; Penicillins/chemical synthesis; Penicillins/pharmacology; Amino Acid Sequence; Animals; Cell Line; Computer Graphics; Crystallography, X-Ray; Dogs; Giant Cells/drug effects; HIV-1/enzymology; Molecular Sequence Data; Structure-Activity Relationship

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Penicillins / HIV Protease Inhibitors Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1994 Document type: Article Affiliation country: United kingdom Country of publication: United States

Search on Google

Add to My VHL

XML

PubMed Links