Chronic myelogenous leukemia: molecular diagnostic considerations.
Hum Pathol
; 25(6): 594-7, 1994 Jun.
Article
in En
| MEDLINE
| ID: mdl-8013950
ABSTRACT
Chronic myelogenous leukemia (CML) is associated in 95% of cases with the Philadelphia chromosome (Ph1) by cytogenetic analysis. This acquired karyotypic abnormality is the product of a balanced translocation between the c-abl oncogene on chromosome 9 and the breakpoint cluster region (BCR) gene on chromosome 22. The resulting BCR/c-abl hybrid gene is actively transcribed and is considered essential in the pathogenesis of this disease. Southern blot- and polymerase chain reaction (PCR)-based tests for the detection of this rearrangement have been introduced over the last decade. These molecular tests are useful adjuncts to cytogenetic analysis in CML and may provide useful clinical information in certain instances.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/
Chromosome Aberrations
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Hum Pathol
Journal subject:
PATOLOGIA
Year:
1994
Document type:
Article