High-resolution structure of an engineered biologically potent insulin monomer, B16 Tyr-->His, as determined by nuclear magnetic resonance spectroscopy.

Ludvigsen, S; Roy, M; Thøgersen, H; Kaarsholm, N C

Ludvigsen, S; Roy, M; Thøgersen, H; Kaarsholm, N C.

Affiliation

Ludvigsen S; Novo Research Institute, Novo Nordisk A/S, Bagsvaerd, Denmark.

Biochemistry ; 33(26): 7998-8006, 1994 Jul 05.

Article in En | MEDLINE | ID: mdl-8025104

Subject(s)

Insulin/analogs & derivatives; Amino Acid Sequence; Circular Dichroism; Computer Simulation; Humans; Hydrogen-Ion Concentration; Insulin/chemistry; Insulin/genetics; Insulin/metabolism; Insulin/pharmacology; Magnetic Resonance Spectroscopy; Mathematical Computing; Molecular Sequence Data; Mutation; Protein Conformation; Protein Engineering; Protein Folding

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Collection: 01-internacional Database: MEDLINE Main subject: Insulin Limits: Humans Language: En Journal: Biochemistry Year: 1994 Document type: Article Affiliation country: Denmark

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