Evaluation of adjuvant therapy after surgery for primary carcinoma of the fallopian tube.
Arch Gynecol Obstet
; 255(1): 19-24, 1994.
Article
in En
| MEDLINE
| ID: mdl-8042874
ABSTRACT
OBJECTIVE:
To evaluate the impact of postoperative therapy (chemotherapy vs. irradiation) on overall survival.DESIGN:
A nationwide retrospective analysis.SETTING:
Hanusch-Krankenhaus, Department of Gynaecology,SUBJECTS:
115 patients with histologically proved primary carcinoma of the Fallopian tube 49 received six treatment cycles of a cis-platinum regimen (group I), 24 patients were treated by full irradiation using 50 Gray minimum (group II). The two groups had a similar distribution of stage I and II; in the more advanced stages chemotherapy was the predominant method of treatment.RESULTS:
The five-year survival rate was 53% for women receiving irradiation as against 27% for those given cis-platinum. If the analysis was restricted to those patients with comparable stage I and stage II lesions, the p-value (0.07) was of borderline significance. There was no advantage in adding abdominal to pelvic irradiation (P = 0.62).CONCLUSIONS:
Stage I and stage II carcinoma is probably better treated postoperatively by radiotherapy than chemotherapy. Chemotherapy may have more therapeutic potential in patients with more advanced lesions.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma
/
Antineoplastic Combined Chemotherapy Protocols
/
Fallopian Tube Neoplasms
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Arch Gynecol Obstet
Journal subject:
GINECOLOGIA
/
OBSTETRICIA
Year:
1994
Document type:
Article
Affiliation country:
Austria