HLA-D alleles associated with generalized disease, localized disease, and putative immunity in Onchocerca volvulus infection.
Proc Natl Acad Sci U S A
; 91(16): 7515-9, 1994 Aug 02.
Article
in En
| MEDLINE
| ID: mdl-8052611
ABSTRACT
Human infections with the tissue nematode Onchocerca volvulus result in a variety of clinical conditions that possibly include protective immunity. In a West African area hyperendemic for human onchocerciasis, 120 residents were classified according to clinical and laboratory findings as presenting with generalized onchocerciasis, localized onchocerciasis, or as being putatively immune. The three groups differed in the distribution of HLA-D variants as determined by DNA typing. The most pronounced differences were found among alleles of the DQ loci. The haplotype DQA1*0501-DQB1*0301 was significantly more frequent among putatively immune individuals than among patients with generalized or localized disease. Conversely, DQA1*0101-DQB1*0501 and, independently, the allele DQB1*0201 were more frequent in generalized disease than in localized disease or putative immunity. In these correlations, the frequencies of allelic variants were in localized disease intermediate to those of the two other groups. The only distinct association found with localized disease was that of the DP allele DPB1*0402. The findings indicate that HLA-D variants influence the course of O. volvulus infection and help to define a state that may reflect protective immunity.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Onchocerciasis
/
HLA-D Antigens
/
Genes, MHC Class II
/
Onchocerca volvulus
Type of study:
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Animals
/
Child
/
Humans
/
Middle aged
Country/Region as subject:
Africa
Language:
En
Journal:
Proc Natl Acad Sci U S A
Year:
1994
Document type:
Article
Affiliation country:
Germany