A Chinese hamster fibroblast mutant defective in thrombin-induced signaling has a low level of phospholipase C-beta 1.

Fee, J A; Monsey, J D; Handler, R J; Leonis, M A; Mullaney, S R; Hope, H M; Silbert, D F

Fee, J A; Monsey, J D; Handler, R J; Leonis, M A; Mullaney, S R; Hope, H M; Silbert, D F.

Affiliation

Fee JA; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110.

J Biol Chem ; 269(34): 21699-708, 1994 Aug 26.

Article in En | MEDLINE | ID: mdl-8063814

Subject(s)

Isoenzymes/genetics; Mutation; Signal Transduction; Thrombin/metabolism; Type C Phospholipases/genetics; Animals; Arachidonic Acid/metabolism; Biological Transport; Cell Compartmentation; Cricetinae; Cricetulus; Down-Regulation; Fibroblasts/cytology; Fibroblasts/enzymology; Phosphatidylinositols/metabolism; Phospholipase C beta; Phospholipases A/metabolism; Sodium-Hydrogen Exchangers/metabolism; Substrate Specificity; Tetradecanoylphorbol Acetate/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Type C Phospholipases / Thrombin / Signal Transduction / Isoenzymes / Mutation Limits: Animals Language: En Journal: J Biol Chem Year: 1994 Document type: Article

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