Phenotypic reversion induced by anthracyclines in ras oncogene-expressed cells; structure-activity relationships.
Biol Pharm Bull
; 17(4): 527-30, 1994 Apr.
Article
in En
| MEDLINE
| ID: mdl-8069262
ABSTRACT
Several antitumor anthracyclines, including those in preclinical stages, were examined for their action in reversing tumorous phenotypes of H- or K-ras 3T3 cells (NIH3T3 cells transformed by human H- or K-ras oncogene) into normal phenotypes, such as flattened cell morphology, anchorage dependent cell growth, etc. (referred to as anti-ras activity). The study elucidated relationships between the chemical structure of anthracyclines and the anti-ras activity. The human tumor cell line T24, which has a mutated H-ras gene, responded to the anthracyclines, as did K- or H-ras 3T3 cells, in respect to the phenotypic alterations. Pirarubicin was more than 4 times as active as aclarubicin in inhibiting the growth of solid tumors of K-ras 3T3 cells in nude mice, possibly reflecting a difference in anti-ras activity between the two antibiotics.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genes, ras
/
Antibiotics, Antineoplastic
/
Neoplasms, Experimental
Limits:
Animals
/
Humans
Language:
En
Journal:
Biol Pharm Bull
Journal subject:
BIOQUIMICA
/
FARMACOLOGIA
Year:
1994
Document type:
Article
Affiliation country:
Japan