Changes in subcellular doxorubicin distribution and cellular accumulation alone can largely account for doxorubicin resistance in SW-1573 lung cancer and MCF-7 breast cancer multidrug resistant tumour cells.

Schuurhuis, G J; van Heijningen, T H; Cervantes, A; Pinedo, H M; de Lange, J H; Keizer, H G; Broxterman, H J; Baak, J P; Lankelma, J

Schuurhuis, G J; van Heijningen, T H; Cervantes, A; Pinedo, H M; de Lange, J H; Keizer, H G; Broxterman, H J; Baak, J P; Lankelma, J.

Affiliation

Schuurhuis GJ; Department of Medical Oncology, Free University, The Netherlands.

Br J Cancer ; 68(5): 898-908, 1993 Nov.

Article in En | MEDLINE | ID: mdl-8105865

Subject(s)

Breast Neoplasms/metabolism; Doxorubicin/pharmacokinetics; Lung Neoplasms/metabolism; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms/drug therapy; Carrier Proteins/analysis; Cell Nucleus/metabolism; Doxorubicin/pharmacology; Drug Resistance; Fluorescence; Humans; Lung Neoplasms/drug therapy; Membrane Glycoproteins/analysis; Tumor Cells, Cultured; Verapamil/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Doxorubicin / Lung Neoplasms Limits: Humans Language: En Journal: Br J Cancer Year: 1993 Document type: Article Affiliation country: Netherlands Country of publication: United kingdom

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