Protein kinase C alpha mediates phospholipase D activation by nucleotides and phorbol ester in Madin-Darby canine kidney cells. Stimulation of phospholipase D is independent of activation of polyphosphoinositide-specific phospholipase C and phospholipase A2.

Balboa, M A; Firestein, B L; Godson, C; Bell, K S; Insel, P A

Balboa, M A; Firestein, B L; Godson, C; Bell, K S; Insel, P A.

Affiliation

Balboa MA; Department of Pharmacology 0636, University of California at San Diego, La Jolla 92093-0636.

J Biol Chem ; 269(14): 10511-6, 1994 Apr 08.

Article in En | MEDLINE | ID: mdl-8144636

Subject(s)

Glycerophospholipids; Nucleotides/pharmacology; Phospholipase D/metabolism; Protein Kinase C/metabolism; Tetradecanoylphorbol Acetate/pharmacology; Animals; Arachidonic Acid/metabolism; Calcium/metabolism; Cells, Cultured; Dogs; Enzyme Activation; Kidney/cytology; Kidney/drug effects; Kidney/enzymology; Neomycin/pharmacology; Phosphatidic Acids/metabolism; Phosphatidylinositol Diacylglycerol-Lyase; Phospholipase D/drug effects; Phospholipases A/metabolism; Phospholipases A2; Phosphoric Diester Hydrolases/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Phospholipase D / Protein Kinase C / Tetradecanoylphorbol Acetate / Glycerophospholipids / Nucleotides Limits: Animals Language: En Journal: J Biol Chem Year: 1994 Document type: Article

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