The early changes in salivary gland function during and after radiotherapy given for head and neck cancer.
Radiother Oncol
; 30(1): 26-32, 1994 Jan.
Article
in En
| MEDLINE
| ID: mdl-8153377
ABSTRACT
The salivary gland function of 47 patients treated by radical radiotherapy (CHART or conventionally fractionated treatment) for head and neck cancer has been studied before, during and for up to 12 weeks from the start of treatment. Pronounced falls in salivary flow and pH are seen once radiotherapy has commenced, particularly when both parotid glands are included in the treatment volume. The initial rate of reduction in flow reflects the rate of delivery of treatment. The parotid glands show the greatest sensitivity to radiotherapy compared with the other salivary glands and reduction in salivary flow is dependent on both dose and the proportion of the gland included in the treatment volume. These early changes in salivary gland function are as marked for patients receiving either CHART or conventionally fractionated treatment, so differing from the late changes which have been shown to be less evident after CHART.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Radiation Injuries
/
Salivary Glands
/
Salivation
/
Head and Neck Neoplasms
Type of study:
Clinical_trials
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Radiother Oncol
Year:
1994
Document type:
Article
Affiliation country:
United kingdom